Campus Directory: Roy Golsteyn

University of Lethbridge

Roy Golsteyn
Faculty
Biological Sciences Department
Office: SA9222
Phone: (403) 332-4553
Email:
Lab
Room: SA9252
Phone: (403) 332-4418

Degrees

Ph.D. (Biochemistry), University of Cambridge
MSc, Medical Biochemistry, University of Calgary
BSc, Biological Sciences, University of Lethbridge

Expertise

Cancer Research, Cell division, DNA damage, Pharmaceutical industry

Research Areas

Understanding how cancer cells divide, Checkpoint adaptation

Previous Research Areas

Drug discovery, Cancer research, Small molecules, Cell cycle, Cell motility

Alternate Languages

French

About Me

Courses

Biol 3105 Cell Signalling
Biol 3115 Cell Growth

Biography

PhD Biochemistry University of Cambridge

Senior Scientist in Cancer Drug Discovery
Servier Pharmaceutical Company, Paris, France

Selected Publications

1. Growing NHPS for the Future: the 16th Annual Natural Health Products Research Conference and Tradeshow. Journal of Natural Health Product Research 1:1-23. doi.org/10.33211/jnhpr.5 2019.

2. Golsteyn, R.M. 2018 Getting anti-cancer chemicals into the clinic- a long but essential path. Genome Alberta 29 March 2018.

3. Swift, L.H. and R.M. Golsteyn. Experimental determination of checkpoint adaptation by mitotic shake-off and microscopy. Methods in Molecular Biology. 1769:159-168 doi: 10.1007/978-1-4939-7780-2_10.2018.

4. Kalsbeek, D. and R.M. Golsteyn. "Checkpoint adaptation and micronuclei formation as mechanisms that contribute to genomic instability in human cells." International Journal of Molecular Sciences.18. 2344; doi:10.3390/ijms18112344 2017.

5. Bosco, A. and R.M. Golsteyn. Emerging anti-mitotic activities and other bio-activities of sesquiterpene compounds upon human cells. Molecules. 22:459-480. 2017. doi:10.3390/molecules22030459

6. Lewis, C.W. and R.M. Golsteyn. Cancer cells that survive checkpoint adaptation contain micronuclei that harbour damaged DNA. Cell Cycle. 15:3131-3145. 2016.

7. Swift, L.H. and R.M. Golsteyn. Cytotoxic amounts of cisplatin induce either checkpoint adaptation or apoptosis in a concentration dependent manner in cancer cells. Biology of the Cell. 108:127-148. 2016.

8. Golsteyn, R.M. Cyclin Dependent Kinases (Cdks), Encyclopedia of Cancer, Springer, M. Schwab. Ed. 3rd Edition 2016.

9. Swift, L.H. and R.M. Golsteyn. "The relationship between checkpoint adaptation and mitotic catastrophe in genomic changes in cancer cells." In Genome Stability. Ed. Kovalchuk, I. and Kovalchuk, O. Elsevier, 2016.

10. Lewis, C.W., R.G. Taylor, and R.M. Golsteyn. "Measurement of Cdk1/cyclin B kinase activity by specific antibodies and western blotting." Methods in Molecular Biology. 1342:337-348. 2016.

11. Kernéis, S., L.H. Swift, C.W. Lewis, C. Bruyère, N. Oumata, P. Colas, S. Ruchaud, J. Bain and R.M. Golsteyn. "Natural product extracts of the Canadian prairie plant, Thermopsis rhombifolia, have anti-cancer activity in phenotypic cell based assays." Natural Product Research. 29:1026-1034. 2015.

In The Media

Media - Name - Title - Date
1. The Lethbridge Herald (newspaper). "U of L names Alumni Honour Society Inductees." 30 August 2019.

2. Western Producer (newpaper). "Native plants could provide new antibiotics." 6 June 2019.

3. The Lethbridge Herald (newspaper). "Funding to Benefit University." 19 September 2017.

4. The Lethbridge Herald (newspaper). "U of L Researcher studying prairie plants for medicinal purposes." 6 September 2017.

5. Prairie Post (newspaper) "University of Lethbridge professor and students pick plants for medicinal properties this summer." 29 August 2017.

6. CBC Calgary Eye-opener Radio Interview (CBC Radio 1) "Notes from the field: Wild flowers and cancer research." 19 June 2017.

Research Interests

The Prairie to Pharmacy Program

We discover and use natural products from Canadian plants. Our research takes us into:

Mechanisms of how cancer cells work
Natural product chemistry
Imaging technology including drones
Traditional knowledge and recognition of local First Nation communities


Interested students and recent PhD graduates are invited to apply for research positions.

Current Research and Creative Activity

TitleLocationGrant InformationPrincipal InvestigatorCo Researchers
A new direction in cancer research: Testing the role of epigenetics in failed cell division Lethbridge, AB University of Lethbridge Research Fund, 2010-2011.

Roy Golsteyn
An inverted light microscope to observe human cancer cells Lethbridge, AB Alberta Cancer Foundation, 2010-2011.

Roy Golsteyn
Associate Professor, Lethbridge, AB, Canada Lethbridge, AB Roy Golsteyn
Checkpoint adaptation: a molecular analysis of how human cells respond to genotoxic events Lethbridge, AB Alberta Ingenuity/Innovation, 2010-2013.

Roy Golsteyn

Previous Research

TitleGrant AgencyCompletion Date
Characterization of Checkpoint adaptation in human cancer cells Alberta Cancer Board 2008-2010 2010
Mitotic catastrophe in human cancer cells University of Lethbridge Start-up funds 2007-2009 2009
Mitotic catastrophe, CNRS French Embassy of Canada, 2008. 2008
Inhibitors of protein kinases Institut de Recherches Servier 2007
Role of Cdc25C phosphorylation in DNA damage CIFRE (Conventions Industrielles de Formation par la Recherche, France) 2007


Edit this Content