Campus Directory: Roy Golsteyn

University of Lethbridge

Roy Golsteyn
Biological Sciences Department
Office: D870 (University Hall)
Phone: (403) 332-4553


Ph.D. (Biochemistry), University of Cambridge
MSc, Medical Biochemistry, University of Calgary
BSc, Biological Sciences, University of Lethbridge


Cancer Research, Cell division, DNA damage, Pharmaceutical industry

Research Areas

Understanding how cancer cells divide, Checkpoint adaptation

Previous Research Areas

Drug discovery, Cancer research, Small molecules, Cell cycle, Cell motility

Alternate Languages


Office Hours

by appointment 1:00 PM to 5:00 PM

About Me


Biol 3105 Cell Signalling
Biol 3115 Cell Growth


PhD Biochemistry University of Cambridge

Senior Scientist in Cancer Drug Discovery
The Servier Pharmaceutical Company, Paris, France

Selected Publications

1. Swift, L.H. and R.M. Golsteyn. Experimental determination of checkpoint adaptation by mitotic shake-off and microscopy. Methods in Molecular Biology. In press. 2017.

2. Kalsbeek, D. and R.M. Golsteyn. "Checkpoint adaptation and micronuclei formation as mechanisms that contribute to genomic instability in human cells." International Journal of Molecular Sciences. In press 2017.

3. Bosco, A. and R.M. Golsteyn. Emerging anti-mitotic activities and other bio-activities of sesquiterpene compounds upon human cells. Molecules. 22:459-480. 2017. doi:10.3390/molecules22030459

4. Lewis, C.W. and R.M. Golsteyn. Cancer cells that survive checkpoint adaptation contain micronuclei that harbour damaged DNA. Cell Cycle. 15:3131-3145. 2016.

5. Swift, L.H. and R.M. Golsteyn. Cytotoxic amounts of cisplatin induce either checkpoint adaptation or apoptosis in a concentration dependent manner in cancer cells. Biology of the Cell. 108:127-148. 2016.

6. Golsteyn, R.M. Cyclin Dependent Kinases (Cdks), Encyclopedia of Cancer, Springer, M. Schwab. Ed. 3rd Edition 2016.

7. Swift, L.H. and R.M. Golsteyn. "The relationship between checkpoint adaptation and mitotic catastrophe in genomic changes in cancer cells." In Genome Stability. Ed. Kovalchuk, I. and Kovalchuk, O. Elsevier, 2016.

8. Lewis, C.W., R.G. Taylor, and R.M. Golsteyn. "Measurement of Cdk1/cyclin B kinase activity by specific antibodies and western blotting." Methods in Molecular Biology. 1342:337-348. 2016.

9. Kernéis, S., L.H. Swift, C.W. Lewis, C. Bruyère, N. Oumata, P. Colas, S. Ruchaud, J. Bain and R.M. Golsteyn. "Natural product extracts of the Canadian prairie plant, Thermopsis rhombifolia, have anti-cancer activity in phenotypic cell based assays." Natural Product Research. 29:1026-1034. 2015.

In The Media

Media - Name - Title - Date
Radio CBC Radio 1 Notes from the field: Wild flowers and cancer research 19-06-2017

Newspaper Western Producer Program studies Alta plants to use as ammo against cancer 25-05-2017

Newspaper Lethbridge Herald Flower Power: a scientific search for new medicines in prairie plants 16-10-2016

Website U. Lethbridge Prairie view opens new research frontier for Golsteyn 14-10-2016

Trade Journal Leap - Alberta Cancer Foundation University of Lethbridge Bean Counters- Buffalo Bean Oct-16

Newspaper Lethbridge Herald U of L research projects receive $200k in funding 07-08-2015

Newspaper Western Producer Cancer researcher plucking wild flowers 02-07-2015

Research Interests

The Cancer Cell Laboratory focuses on two projects:

1. The Prairie to Pharmacy Program. We are investigating plant species from the prairie ecological zone for novel anti-cancer compounds. This is a multidisciplinary project that includes collaborations with chemists, botanists, and biologists.

2. Checkpoint Adaptation Project. We examine how cancer cells respond to cancer treatments. We are testing the hypothesis that cancer cells undergo a pathway known as "checkpoint adaptation" (entering mitosis with damaged DNA). We use cultured human cells and cell biological techniques such as microscopy, RNA interference, transfection and Western blotting.

Interested students and recent PhD graduates are invited to apply for research positions.

Current Research and Creative Activity

TitleLocationGrant InformationPrincipal InvestigatorCo Researchers
A new direction in cancer research: Testing the role of epigenetics in failed cell division Lethbridge, AB University of Lethbridge Research Fund, 2010-2011.

Roy Golsteyn
An inverted light microscope to observe human cancer cells Lethbridge, AB Alberta Cancer Foundation, 2010-2011.

Roy Golsteyn
Associate Professor, Lethbridge, AB, Canada Lethbridge, AB Roy Golsteyn
Checkpoint adaptation: a molecular analysis of how human cells respond to genotoxic events Lethbridge, AB Alberta Ingenuity/Innovation, 2010-2013.

Roy Golsteyn

Previous Research

TitleGrant AgencyCompletion Date
Characterization of Checkpoint adaptation in human cancer cells Alberta Cancer Board 2008-2010 2010
Mitotic catastrophe in human cancer cells University of Lethbridge Start-up funds 2007-2009 2009
Mitotic catastrophe, CNRS French Embassy of Canada, 2008. 2008
Inhibitors of protein kinases Institut de Recherches Servier 2007
Role of Cdc25C phosphorylation in DNA damage CIFRE (Conventions Industrielles de Formation par la Recherche, France) 2007

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