University of Lethbridge

Selected Publications

Thapa, Rajat, Sparks, Fraser T., Hanif, Wahab, Gulbrandsen, Tine, Sutherland, RJ (2014). Recent memory for socially transmitted food preferences in rats does not depend on the hippocampus. Neurobiology of Learning and Memory, 114: 113 - 116.

Gervais, N.J., Meagan Barrett-Bernstein, M., Sutherland, R.J. Mumby, D.G. (2014). Retrograde and anterograde memory following selective damage to the dorsolateral entorhinal cortex. Neurobiology of Learning and Memory, 116, 14 - 26.

Gulbrandsen, T.L., Sutherland, RJ (2014). Temporary inactivation of the rodent hippocampus: an evaluation of the current methodology. Journal of Neuroscience Methods, 225, 20 - 128.

Clark, R. E., Sutherland, R. J. (2013). The neurobiology of remote memory in the experimental animal. Neurobiology of Learning and Memory, 106, 292-293.

Sparks, FT, Spanswick, SC, Lehmann, H, Sutherland, RJ. (2013) Neither time nor number of context-shock pairings affect long-term dependence of memory on hippocampus. Neurobiology of Learning and Memory, 106, 309 - 315.

Gulbrandsen, T.L., Sparks F., Sutherland, RJ (2013). Interfering with post-learning hippocampal activity does not affect long-term consolidation of a context fear memory outside the hippocampus. Behavioural Brain Research, 240, 103 - 109.

Christie, Gregory J.; Cook, Charles M.; Ward, Brian J.; Tata, M.J. Sutherland, J.M., Sutherland, R.J., Saucier, D.M. (2013). Mental Rotational Ability Is Correlated with Spatial but Not Verbal Working Memory Performance and P300 Amplitude in Males. PLOS ONE, 8 (2) Article Number: e57390 DOI: 10.1371/journal.pone.0057390

Mankin, EA, Sparks, FT, Slayyeh, B, Sutherland, RJ, Leutgeb, S, Leutgeb, JK (2012). Neuronal code for extended time in the hippocampus. Proceedings of the National Academy of Sciences, 109(47), 19462-19467.

Faraji, J, Sutherland, RJ, Metz GA (2011). Stress precipitates functional deficits following striatal silent stroke: A synergistic effect. Exp Neurol, 232(2), 251-260.

Sparks, F, Lehmann, H, Hernandez, K, Sutherland, RJ (2011). Suppression of Neurotoxic Lesion-Induced Seizure Activity: Evidence for a Permanent Role for the Hippocampus in Contextual Memory. PLOS One, 6(11), e27426 DOI 10.1371.

Sutherland, RJ, Lehmann, H. (2011). Alternative conceptions of memory consolidation and the role of the hippocampus at the systems level in rodents. Current Opinion in Neurobiology, 21, 446 - 451.

Faraji, J., Metz, G.A., Sutherland, R.J. (2011). Chronic stress prior to
hippocampal stroke enhances post-stroke spatial deficits in the Ziggurat
task. Neurobiology of Learning and Memory, 95, 335 - 345.

Spanswick, S.C., Lehmann, H., Sutherland, R.J. (2011). A novel animal
model of hippocampal cognitive deficits, slow neurodegeneration, and
neuroregeneration. Journal of Biomedicine and Biotechnology, Journal of
Biomedicine and Biotechnology, in press, (accepted Jan 19, 2011).

Faraji J, Metz GA, Sutherland RJ (2011). Stress after hippocampal
stroke enhances spatial performance in rats. Physiology & Behavior,
102, 389 - 399.

Spanswick, S.C., Epp, J.R., Sutherland, R.J. (2011). Time-course of hippocampal granule cell degeneration and changes in adult neurogenesis after adrenalectomy in rats. Neuroscience, 190, 166 - 176.

Sparks, F, Lehmann, H, Sutherland, RJ (2011). Between-systems memory interference during retrieval. Eur J Neurosci, 34, 780-786.

Spanswick, S.C., Lehmann, H., Sutherland, R.J. (2011). Does the
Regeneration of Hippocampal Neurons Offer Hope for the Treatment of
Cognitive Deficits? Regenerative Medicine, 6(1), 1 - 3.

Spanswick, S.C., Sutherland, R.J. (2010). Object/Context Specific
Memory Deficits Associated With Loss of Hippocampal Granule Cells
After Adrenalectomy in Rats. Learning and Memory, 17(5), 241 - 245.

Faraji, J., Metz, G.A., Sutherland, R.J. (2010). Characterization of
spatial performance in male and female Long-Evans rats by means of
the Morris water task and the ziggurat task. Brain Research Bulletin,
81(1), 164 - 172.

Sutherland, R.J. (2010). Spatial Memory: A Rosetta Stone for Rat and
Human Hippocampal Discourse: Theoretical Comment on GoodrichHunsaker
and Hopkins. Behavioral Neuroscience, 124(3), 434 - 436.

Sutherland, R.J., Sparks, F.T., Lehmann, H. (2010). Hippocampus and
Retrograde Amnesia in the Rat Model: A Modest Proposal for the
Situation of Systems Consolidation. Neuropsychologia, 48(8), 2357 -
2369.

Travis, S.G., Fraser T. Sparks, F.T., Arnold, T., Lehmann, H.,
Sutherland, R.J., Whishaw, I.Q. (2010). Hippocampal damage
produces retrograde but not anterograde amnesia for a cued
location in a spontaneous exploratory task in rats. Hippocampus,
20(9), 1095 - 1104.

Lehmann, H., Sparks, F. T., O'Brien, J., McDonald, R. J.,
Sutherland, R. J. (2010). Retrograde amnesia for fear-potentiated
startle in rats after complete, but not partial, hippocampal
damage. Neuroscience, 167(4), 974 - 984.

Spanswick, S.C., Bray, D., Zelinski, E., Sutherland, R.J. (2009). A Novel
Method for Reliable Nuclear Antibody Detection in Tissue with High
Levels of Pathology-Induced Autofluorescence. Journal of Neuroscience
Methods, 185(1), 45 - 49.

Melvin, N., Sutherland, R.J. (2010). Quantitative caveats of standard
immunohistochemical procedures: Implications for optical disectorbased
designs. Journal of Histochemistry & Cytochemistry, 58(7), 577 -
584.

Faraji, J., Metz, G., Sutherland, R. J. (2009). Stress and Corticosterone
Enhance Cognitive Recovery from Hippocampal Stroke in Rats.
Neuroscience Letters, 462, 248 - 252.

Lehmann, H., Sparks, F.T., Spanswick, S.C., Hadikin, C., McDonald,
R.J., Sutherland, R.J. (2009). Making Context Memories Independent of
the hippocampus. Learning and Memory, 16, 417 - 420.

Sutherland, R.J., O'Brien, J. (2009). The hippocampus and medial
prefrontal cortex are necessary for episodic memory in the rat.
Hippocampus, accepted for publication, 20 March 2009.

Whitlock, J., Sutherland, R.J., Witter, M.P., Moser, M-B., Moser, E.I.
(2008). Navigating from hippocampus to parietal cortex. Proceedings of
the National Academy of Science, 105(39), 14755 - 14762.

Tamminga, J; Koturbash, I; Baker, M; Kutanzi, K; Kathiria, P; Pogribny,
IP; Sutherland, RJ; Kovalchuk, O. (2008). Paternal cranial irradiation
induces distant bystander DNA damage in the germline and leads to
epigenetic alterations in the offspring. Cell Cycle, 7, 1238 - 1245.

Sutherland, R.J., O'Brien, J., Lehmann, H. (2008). Absence of systems
consolidation of fear memories after dorsal, ventral, or complete
hippocampal damage. Hippocampus, 18, 710 - 718.

Epp, JR, Keith, JR, Spanswick, S, Stone, J, Prusky, GT, Sutherland, R.J.
(2008). Retrograde amnesia for visual memories after hippocampal
damage in rats. Learning and Memory, 15, 214-221.

Driscoll, I., Hong, N.S., Craig, L.A., Sutherland, R.J., and McDonald, R.J.
(2008). Enhanced cell death and learning deficits after a mini-stroke in
aged hippocampus. Neurobiology of Aging, 29(12), 1847-1858.

Faraji, J., Lehmann, H., Metz, G., Sutherland, R.J. (2008). Rats with
hippocampal lesions show impaired learning and memory in the ziggurat
task: A new task to evaluate spatial behavior. Behavioural Brain
Research, 189(1), 17 - 31.

Akers, KG; Johnson, TE; Rice, JP; Candelaria, FT; Weisend, MP; Sutherland,
RJ; Redhead, ES; Hamilton, DA. (2008). The relative influence of place
and direction in the Morris water task. Journal of Experimental
Psychology: Animal Behavior Processes, 34(1), 31-53.

Rudy, JW, Sutherland, RJ (2008). Is it Systems or Cellular
Consolidation? Time will tell. An Alternative interpretation of The Morris
Group's Recent Science Paper. Neurobiology of Learning and Memory,
89, 366 - 369.

Harch, PG, Kriedt, C, Van Meter, KW, Sutherland, RJ (2007). Hyperbaric
oxygen therapy improves spatial learning and memory in a rat model of
chronic traumatic brain injury. Brain Research, 1174, 120 - 129.

O'Brien, J. Sutherland, R.J. (2007). Evidence for episodic memory in a
Pavlovian conditioning procedure in rats. Hippocampus, 17, 1149 -
1152.

Tata, MS, Mason, ALO, Sutherland, RJ (2007). Attention Modulates
Responses to Motion Reversals in Human Visual Cortex. Neuroreport,
18(13), 1361 - 1365.

Keith, JR, Wu, Y, Epp, JR, Sutherland, RJ (2007). Fluoxetine and the
Dentate Gyrus: Memory, Recovery of Function, and Electrophysiology.
Behavioural Pharmacology, 18(5-6), 521 - 531.

Lehmann, H., Lacanilao, S., and Sutherland, R. J. (2007). Complete or
Partial Hippocampal Damage Produces Equivalent Retrograde Amnesia
for Recent and Remote Contextual Fear Memories. European Journal of
Neuroscience, 25(5), 1278 - 1286.

Melvin, N. R., Spanswick, S. C., Lehmann, H., and Sutherland. R. J.
(2007). Differential Neurogenesis in the Adult Rat Dentate Gyrus: An
identifiable zone that consistently lacks neurogenesis. European Journal
of Neuroscience, 25 (4), 1023 - 1029.

Bennett, B.M., Reynolds, J.N., Prusky, G.T., Douglas, R.M., Sutherland,
R.J., and Thatcher, G.R.J. (2007). Cognitive deficits in rats after
forebrain cholinergic depletion are reversed by a novel NO mimetic
nitrate ester. Neuropsychopharmacology, 32(3), 505 - 513.

Hamilton, D. A., Akers, K. A., Weisend, M.P., and Sutherland, R. J.
(2007). How do room and apparatus cues control place navigation in the
Morris water task?: Evidence for distinct contributions to a movement
vector. Quarterly Journal of Experimental Psychology, 33(2), 100 - 114.

Spanswick, S., Epp, J.R., Keith, J.R., and Sutherland, R.J. (2007).
Adrenalectomy-induced granule cell degeneration in the hippocampus
causes spatial memory deficits that are not reversed by chronic
treatment with corticosterone or fluoxetine. Hippocampus, 17, 137 -
146.

In The Media

http://albertaventure.com/2013/07/albertas-50-most-influential-people-2013/

http://www.uleth.ca/artsci/news/2011/08/ccbns-dr-robert-sutherland-alberta-ventures-50-most-influential-people-list

http://issuu.com/ulethbridge/docs/sam_fall2010/13

Memory, aging, and the brain; AHFMR Research News; www.ahfmr.ab.ca; Winter 2007.

Imaging centre envy of many; Lethbridge Herald; October 6, 2006.

Sutherland's AHFMR Funding is Renewed; Legend; April 2006.

Researcher gets nearly $1M to study brain; Lethbridge Herald; March 24, 2006.

Faculty and Staff; Community Report 2005-06; http://www.uleth.ca/advancement/comm/Community_Report_0506.pdf

Cell Regeneration Research Could Restore Memory Functions; Legend; April 2005.

An ounce of prevention; AHFMR Research News; www.ahfmr.ab.ca; Winter 2004.

U of L researcher seeking human subjects for FAS study; Lethbridge Herald; February 26, 2004.

Memorable Research; 2003 Community Report.

Neuroscientist Lands $1.25 Million Grant; Legend; September 2002.

One drink is too many; AHFMR Research News; www.ahfmr.ab.ca; Fall 2001.

CCBN Researchers - A"head" of the Game; Legend; November 2001.

Robert returns to Lethbridge to continue his FAS research; Lethbridge Herald; April 2, 2001.

Current Research and Creative Activity

Title	Location	Grant Information	Principal Investigator	Co Researchers
Episodic memory and hippocampus		Natural Science and Engineering Research Council (NSERC), $340,000, 2005-10.	R. Sutherland, University of Lethbridge
Functional aspects of adult hippocampal neurogenesis		National Institutes of Health, $346,000, 2003-08.		R. Sutherland, University of Lethbridge
Hippocampal damage and retrograde amnesia		National Institutes of Health, pending, 2007-12.	R. Sutherland, University of Lethbridge
Hippocampal dentate gyrus damage and cognitive deficits: An evaluation of restoration of function after regrowth of neural circuitry		CIHR PI: RJS, ($683,550), 2010-2015. Canadian Institutes of Health Research, $589,000.
Hippocampal dentate gyrus damage and cognitive deficits: An evaluation of restoration of function after regrowth of neural circuitry		CIHR PI: RJS, ($683,550), 2010-2015. Canadian Institutes of Health Research, $589,000.	R. Sutherland, University of Lethbridge
Hippocampus and episodic memory		NSERC PI: RJS, ($338,335), 2007-2012.
Southern Alberta Group for Epigenetic Studies		CFI NIF Project Leader: RJS, ($8,030,000), 2009-2010.

Previous Research

Title	Grant Agency	Completion Date
Prenatal alcohol effects on adult cortical physiology and cognition	Alberta Heritage Foundation for Medical Research	2001-03
Cytokines and cognition	Natural Sciences and Engineering Research Council (NSERC)	2002-06
Hippocampal damage and retrograde amnesia	National Institutes of Health / National Institute of Mental Health	2002-07
Hippocampal and frontal cortical memory function in Fetal Alcohol Syndrome	National Foundation for Functional Brain Imaging	2000-02
Cortical plasticity and learning. coPI with D. Savage	National Institutes of Health / National Institute on Alcohol Abuse and Alcoholism	1999-2003
Hippocampal damage and retrograde amnesia	NIH/NIMH PI: RJS - ($1,592,000)	2002 - 2008
Functional aspects of adult hippocampal	NIH/NIMH RJS co-PI - (UofL $346,000) neurogenesis	2003 - 2009
Fetal alcohol spectrum disorder prevention project	ACCFCR PI: RJS - ($250,000)	2004 - 2008
CCBN Imaging Centre Upgrade	Alberta Advanced Education & Technology PI: RJS - ($152,000)	2007 - 2009

Curriculum Vitae

My CV