
Roy Golsteyn
- Faculty
- Biological Sciences Department
- Office: SA9222
- Phone: (403) 332-4553
- Email:
- Phone: (403) 332-4553
- Lab
- Room: SA9252
- Phone: (403) 332-4418
- Phone: (403) 332-4418
Degrees
Ph.D. (Biochemistry), University of CambridgeMSc, Medical Biochemistry, University of Calgary
BSc, Biological Sciences, University of Lethbridge
Expertise
Cancer Research, Cell division, DNA damage, Pharmaceutical industryResearch Areas
Understanding how cancer cells divide, Checkpoint adaptationPrevious Research Areas
Drug discovery, Cancer research, Small molecules, Cell cycle, Cell motilityAlternate Languages
FrenchAbout Me
CoursesBiol 3110 Cell Signalling
Biol 4180 Natural Products in Biology
Biography
PhD Biochemistry University of CambridgeSenior Scientist in Cancer Drug Discovery
Servier Pharmaceutical Company, Paris, France
Selected Publications
1. Jan M. Tuescher , Chad R. Beck, Locke Spencer, Benjamin Yeremy, Yutong Shi, Raymond J. Andersen and R.M. Golsteyn. Extracts prepared from a Canadian toxic plant induce light-dependent peri-nuclear vacuoles in human cells. Toxins. In press. 20212. Tuescher, J. D Tailfeathers, SM Kernéis, B Baratte, S Ruchaud, S Bach. R.M. Golsteyn The Canadian prairie plant Thermopsis rhombifolia contains luteolin, a flavone that inhibits cyclin dependent kinase 9 and arrest cells in the G1-Phase of the cell cycle. Journal of Natural Health Product Research 2: 1-14. 2020.
3. Growing NHPS for the Future: the 16th Annual Natural Health Products Research Conference and Tradeshow. Journal of Natural Health Product Research 1:1-23. doi.org/10.33211/jnhpr.5 2019.
4. Golsteyn, R.M. 2018 Getting anti-cancer chemicals into the clinic- a long but essential path. Genome Alberta 29 March 2018.
5. Swift, L.H. and R.M. Golsteyn. Experimental determination of checkpoint adaptation by mitotic shake-off and microscopy. Methods in Molecular Biology. 1769:159-168 doi: 10.1007/978-1-4939-7780-2_10.2018.
6. Kalsbeek, D. and R.M. Golsteyn. "Checkpoint adaptation and micronuclei formation as mechanisms that contribute to genomic instability in human cells." International Journal of Molecular Sciences.18. 2344; doi:10.3390/ijms18112344 2017.
7. Bosco, A. and R.M. Golsteyn. Emerging anti-mitotic activities and other bio-activities of sesquiterpene compounds upon human cells. Molecules. 22:459-480. 2017. doi:10.3390/molecules22030459
8. Lewis, C.W. and R.M. Golsteyn. Cancer cells that survive checkpoint adaptation contain micronuclei that harbour damaged DNA. Cell Cycle. 15:3131-3145. 2016.
9. Swift, L.H. and R.M. Golsteyn. Cytotoxic amounts of cisplatin induce either checkpoint adaptation or apoptosis in a concentration dependent manner in cancer cells. Biology of the Cell. 108:127-148. 2016.
10. Lewis, C.W., R.G. Taylor, and R.M. Golsteyn. "Measurement of Cdk1/cyclin B kinase activity by specific antibodies and western blotting." Methods in Molecular Biology. 1342:337-348. 2016.
In The Media
Media - Name - Title - Date1. The Lethbridge Herald (newspaper). "U of L names Alumni Honour Society Inductees." 30 August 2019.
2. Western Producer (newpaper). "Native plants could provide new antibiotics." 6 June 2019.
3. The Lethbridge Herald (newspaper). "Funding to Benefit University." 19 September 2017.
4. The Lethbridge Herald (newspaper). "U of L Researcher studying prairie plants for medicinal purposes." 6 September 2017.
5. Prairie Post (newspaper) "University of Lethbridge professor and students pick plants for medicinal properties this summer." 29 August 2017.
6. CBC Calgary Eye-opener Radio Interview (CBC Radio 1) "Notes from the field: Wild flowers and cancer research." 19 June 2017.
Research Interests
The Prairie to Pharmacy ProgramWe discover and use natural products from Canadian plants. Our research takes us into:
Natural products in biology and medicine
Natural product chemistry
Imaging technology including drones
Traditional knowledge and recognition of local First Nation communities
Interested students and recent PhD graduates are invited to apply for research positions.
Current Research and Creative Activity
Title | Location | Grant Information | Principal Investigator | Co Researchers |
---|---|---|---|---|
A new direction in cancer research: Testing the role of epigenetics in failed cell division | Lethbridge, AB |
University of Lethbridge Research Fund, 2010-2011.
|
Roy Golsteyn | |
An inverted light microscope to observe human cancer cells | Lethbridge, AB |
Alberta Cancer Foundation, 2010-2011.
|
Roy Golsteyn | |
Associate Professor, Lethbridge, AB, Canada | Lethbridge, AB | Roy Golsteyn | ||
Checkpoint adaptation: a molecular analysis of how human cells respond to genotoxic events | Lethbridge, AB |
Alberta Ingenuity/Innovation, 2010-2013.
|
Roy Golsteyn |
Previous Research
Title | Grant Agency | Completion Date |
---|---|---|
Characterization of Checkpoint adaptation in human cancer cells | Alberta Cancer Board 2008-2010 | 2010 |
Mitotic catastrophe in human cancer cells | University of Lethbridge Start-up funds 2007-2009 | 2009 |
Mitotic catastrophe, CNRS | French Embassy of Canada, 2008. | 2008 |
Inhibitors of protein kinases | Institut de Recherches Servier | 2007 |
Role of Cdc25C phosphorylation in DNA damage | CIFRE (Conventions Industrielles de Formation par la Recherche, France) | 2007 |