University of Lethbridge

About Me

Courses

Biol 3110 Cell Signalling
Biol 4180 Natural Products in Biology

Biography

PhD Biochemistry University of Cambridge

Senior Scientist in Cancer Drug Discovery
Servier Pharmaceutical Company, Paris, France

Selected Publications

1. Jan M. Tuescher , Chad R. Beck, Locke Spencer, Benjamin Yeremy, Yutong Shi, Raymond J. Andersen and R.M. Golsteyn. Extracts prepared from a Canadian toxic plant induce light-dependent peri-nuclear vacuoles in human cells. Toxins. In press. 2021

2. Tuescher, J. D Tailfeathers, SM Kernéis, B Baratte, S Ruchaud, S Bach. R.M. Golsteyn The Canadian prairie plant Thermopsis rhombifolia contains luteolin, a flavone that inhibits cyclin dependent kinase 9 and arrest cells in the G1-Phase of the cell cycle. Journal of Natural Health Product Research 2: 1-14. 2020.

3. Growing NHPS for the Future: the 16th Annual Natural Health Products Research Conference and Tradeshow. Journal of Natural Health Product Research 1:1-23. doi.org/10.33211/jnhpr.5 2019.

4. Golsteyn, R.M. 2018 Getting anti-cancer chemicals into the clinic- a long but essential path. Genome Alberta 29 March 2018.

5. Swift, L.H. and R.M. Golsteyn. Experimental determination of checkpoint adaptation by mitotic shake-off and microscopy. Methods in Molecular Biology. 1769:159-168 doi: 10.1007/978-1-4939-7780-2_10.2018.

6. Kalsbeek, D. and R.M. Golsteyn. "Checkpoint adaptation and micronuclei formation as mechanisms that contribute to genomic instability in human cells." International Journal of Molecular Sciences.18. 2344; doi:10.3390/ijms18112344 2017.

7. Bosco, A. and R.M. Golsteyn. Emerging anti-mitotic activities and other bio-activities of sesquiterpene compounds upon human cells. Molecules. 22:459-480. 2017. doi:10.3390/molecules22030459

8. Lewis, C.W. and R.M. Golsteyn. Cancer cells that survive checkpoint adaptation contain micronuclei that harbour damaged DNA. Cell Cycle. 15:3131-3145. 2016.

9. Swift, L.H. and R.M. Golsteyn. Cytotoxic amounts of cisplatin induce either checkpoint adaptation or apoptosis in a concentration dependent manner in cancer cells. Biology of the Cell. 108:127-148. 2016.

10. Lewis, C.W., R.G. Taylor, and R.M. Golsteyn. "Measurement of Cdk1/cyclin B kinase activity by specific antibodies and western blotting." Methods in Molecular Biology. 1342:337-348. 2016.

In The Media

Media - Name - Title - Date
1. The Lethbridge Herald (newspaper). "U of L names Alumni Honour Society Inductees." 30 August 2019.

2. Western Producer (newpaper). "Native plants could provide new antibiotics." 6 June 2019.

3. The Lethbridge Herald (newspaper). "Funding to Benefit University." 19 September 2017.

4. The Lethbridge Herald (newspaper). "U of L Researcher studying prairie plants for medicinal purposes." 6 September 2017.

5. Prairie Post (newspaper) "University of Lethbridge professor and students pick plants for medicinal properties this summer." 29 August 2017.

6. CBC Calgary Eye-opener Radio Interview (CBC Radio 1) "Notes from the field: Wild flowers and cancer research." 19 June 2017.

Research Interests

The Prairie to Pharmacy Program

We discover and use natural products from Canadian plants. Our research takes us into:

Natural products in biology and medicine
Natural product chemistry
Imaging technology including drones
Traditional knowledge and recognition of local First Nation communities


Interested students and recent PhD graduates are invited to apply for research positions.

Current Research and Creative Activity

Title	Location	Grant Information	Principal Investigator	Co Researchers
A new direction in cancer research: Testing the role of epigenetics in failed cell division	Lethbridge, AB	University of Lethbridge Research Fund, 2010-2011.	Roy Golsteyn
An inverted light microscope to observe human cancer cells	Lethbridge, AB	Alberta Cancer Foundation, 2010-2011.	Roy Golsteyn
Associate Professor, Lethbridge, AB, Canada	Lethbridge, AB		Roy Golsteyn
Checkpoint adaptation: a molecular analysis of how human cells respond to genotoxic events	Lethbridge, AB	Alberta Ingenuity/Innovation, 2010-2013.	Roy Golsteyn

Previous Research

Title	Grant Agency	Completion Date
Characterization of Checkpoint adaptation in human cancer cells	Alberta Cancer Board 2008-2010	2010
Mitotic catastrophe in human cancer cells	University of Lethbridge Start-up funds 2007-2009	2009
Mitotic catastrophe, CNRS	French Embassy of Canada, 2008.	2008
Inhibitors of protein kinases	Institut de Recherches Servier	2007
Role of Cdc25C phosphorylation in DNA damage	CIFRE (Conventions Industrielles de Formation par la Recherche, France)	2007

Internet Links

https://www.prairietopharmacy.com/