University of Lethbridge

About Me

Courses

Biol 3110 Cell Signalling
Biol 4180 Natural Products in Biology

Biography

PhD Biochemistry University of Cambridge

Cancer Drug Discovery
Servier Pharmaceutical Company, Paris, France

Selected Publications

1. Bosco, A; Molina, L; Kernéis, SM; Hatzopoulos, G; Favez, T; Gönczy, P; Tantapakul, C; Maneerat, W; Yeremy, B; Williams, DE; Andersen, RJ; Golsteyn, RM. (2021). Pulchelloid A, a sesquiterpene lactone from the Canadian prairie plant Gaillardia aristata inhibits mitosis in human cells. Molecular Biology Reports, 48, 5459-5471.

2. Jan M. Tuescher , Chad R. Beck, Locke Spencer, Benjamin Yeremy, Yutong Shi, Raymond J. Andersen and R.M. Golsteyn. Extracts prepared from a Canadian toxic plant induce light-dependent peri-nuclear vacuoles in human cells. Toxins. 13. e138. 2021

3. Tuescher, J. D Tailfeathers, SM Kernéis, B Baratte, S Ruchaud, S Bach. R.M. Golsteyn The Canadian prairie plant Thermopsis rhombifolia contains luteolin, a flavone that inhibits cyclin dependent kinase 9 and arrest cells in the G1-Phase of the cell cycle. Journal of Natural Health Product Research 2: 1-14. 2020.

4. Molina, L; Williams, DE; Andersen, RJ; Golsteyn, RM. (2021). Isolation of a natural product with anti-mitotic activity from a toxic Canadian prairie plant. Heliyon, 7, e07131.

5. Swift, L.H. and R.M. Golsteyn. Experimental determination of checkpoint adaptation by mitotic shake-off and microscopy. Methods in Molecular Biology. 1769:159-168 doi: 10.1007/978-1-4939-7780-2_10. 2018.

6. Kalsbeek, D. and R.M. Golsteyn. "Checkpoint adaptation and micronuclei formation as mechanisms that contribute to genomic instability in human cells." International Journal of Molecular Sciences.18. 2344; doi:10.3390/ijms18112344 2017.

7. Bosco, A. and R.M. Golsteyn. Emerging anti-mitotic activities and other bio-activities of sesquiterpene compounds upon human cells. Molecules. 22:459-480. 2017. doi:10.3390/molecules22030459

8. Lewis, C.W. and R.M. Golsteyn. Cancer cells that survive checkpoint adaptation contain micronuclei that harbour damaged DNA. Cell Cycle. 15:3131-3145. 2016.

9. Swift, L.H. and R.M. Golsteyn. Cytotoxic amounts of cisplatin induce either checkpoint adaptation or apoptosis in a concentration dependent manner in cancer cells. Biology of the Cell. 108:127-148. 2016.

In The Media

Media - Name - Title - Date

1. Evening news. Global, CTV. (2020, January 10). Interviews highlighting the Power Corporation and Canada Life Donation to UoL and Prairie to Pharmacy Program. Evening news. Global, CTV.

2. Aboriginal People Television Network -APTN (2019, November 29). Prairie to Pharmacy Program and collaboration with First Nation communities. Evening news. Aboriginal People Television Network.

3. The Lethbridge Herald (newspaper). "U of L names Alumni Honour Society Inductees." 30 August 2019.

4. Western Producer (newpaper). "Native plants could provide new antibiotics." 6 June 2019.

5. The Lethbridge Herald (newspaper). "Funding to Benefit University." 19 September 2017.

6. The Lethbridge Herald (newspaper). "U of L Researcher studying prairie plants for medicinal purposes." 6 September 2017.

7. CBC Calgary Eye-opener Radio Interview (CBC Radio 1) "Notes from the field: Wild flowers and cancer research." 19 June 2017.

Research Interests

The Prairie to Pharmacy Program

We discover and use natural products from Canadian plants. Our research takes us into:

Natural products in biology and medicine
Natural product chemistry
Imaging technology including drones
Traditional knowledge and recognition of local First Nation communities


Interested students and recent PhD graduates are invited to apply for research positions.

Current Research and Creative Activity

Title	Location	Grant Information	Principal Investigator	Co Researchers
Investigation of cell division using new natural products	Lethbridge, AB	NSERC.	Roy Golsteyn
Natural products: Infrastructure	Lethbridge, AB	Canada Foundation for Innovation.	Roy Golsteyn
Prairie to Pharmacy Program	Lethbridge, AB	Power Corp. Canada.	Roy Golsteyn

Internet Links

https://www.prairietopharmacy.com/